Key result
Detailed action potential models for canine atrial cells were developed and incorporated into a tissue strand model to quantify conditions for conduction abnormalities at rapid pacing rates.
Developed a computational platform of heterogeneous canine atrial action potential models to study substrates for rapid atrial arrhythmias.
Region-specific canine atrial AP models quantify heterogeneity; extends computational tools but leaves open human arrhythmia translation.
Heterogeneity in the electrical action potential (AP) properties can provide a substrate for atrial arrhythmias, especially at rapid pacing rates. In order to quantify such substrates, we develop a family of detailed AP models for canine atrial cells. An existing model for the canine right atrial (RA) myocyte was modified based on electrophysiological data from dog to create new models for the canine left atrium (LA), the interatrial Bachmann's bundle (BB), and the pulmonary vein (PV). The heterogeneous AP models were incorporated into a tissue strand model to simulate the AP propagation, and used to quantify conditions for conduction abnormalities (primarily, conduction block at rapid pacing rated) in the canine atria.
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Aslanidi et al. (2011) studied Atrial arrhythmias. Computational action potential models was evaluated on Conduction abnormalities (conduction block at rapid pacing rates). Detailed action potential models for canine atrial cells were developed and incorporated into a tissue strand model to quantify conditions for conduction abnormalities at rapid pacing rates.
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