Key result
Bioactive tripeptides lower systolic blood pressure by ~4 mmHg compared to placebo.
Meta-Analysis (n=1,500)
Mean Difference: -4 (95% CI -5.9–-2.1)
p-value: p=< 0.001
A meta-analysis of possible antihypertensive effects of small doses of bioactive tripeptides isoleucine-proline-proline and valine-proline-proline in commercial milk products or tablets was carried out. A random effects model was used on 19 randomized, placebo-controlled clinical intervention trials (published 1996-October 2010) consisting of about 1500 prehypertensive or mildly hypertensive subjects.The overall blood pressure lowering for systolic blood pressure was -4.0 mmHg (95% CI -5.9 to -2.1 mmHg, P < 0.001) and for diastolic blood pressure -1.9 mmHg (95% CI -3.1 to -0.8 mmHg, P < 0.001). However, a positive effect was not reported in all the studies. The results suggest that rather small daily doses of the lactotripeptides in different functional food products may offer a valuable option as a non-pharmacological treatment of prehypertension or mild hypertension as part of life-style advice.
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Turpeinen et al. (2012) conducted a meta-analysis in Prehypertension or mild hypertension (n=1,500). Bioactive tripeptides isoleucine-proline-proline and valine-proline-proline vs. Placebo was evaluated on Change in systolic blood pressure (MD -4.0 mmHg, 95% CI -5.9 to -2.1, p=< 0.001). Bioactive tripeptides isoleucine-proline-proline and valine-proline-proline reduced systolic blood pressure by 4.0 mmHg (95% CI -5.9 to -2.1; P<0.001) compared to placebo.
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