Key result
Higher WBC/TP ratio is linked to ~9.6-fold higher in-hospital mortality per SD in infant heart failure.
Why the study?
The study aimed to correlate the WBC/TP ratio with mortality in infant heart failure and develop a predictive risk model.
Does an elevated WBC/TP ratio predict in-hospital mortality in infants with heart failure?
Cohort (n=544)
No
Does an elevated WBC/TP ratio predict in-hospital mortality in infants with heart failure?
The WBC/TP ratio provides a novel, inexpensive clinical tool linking inflammation and nutritional status to predict in-hospital mortality in pediatric heart failure patients.
Answers are grounded in this paper and cite their sources.
May support risk stratification in infant heart failure but should not yet change practice; leaves open need for prospective validation of this association.
The study analyzed 544 infants (1-36 months) with heart failure, aiming to correlate WBC/TP ratio with mortality and create a predictive model. Lasso regression identified significant mortality-associated clinical indices; logistic regression then built a death prediction model with an AUC of 0.755. Calibration and DCA curves indicated model accuracy and clinical utility. Risk stratification revealed higher mortality in the high-risk group, emphasizing WBC/TP as predictors and the model's value for early high-risk patient identification in infant heart failure.
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Shang et al. (2025) conducted a cohort in Infant heart failure (n=544). Elevated white blood cell count to total protein ratio (WBC/TP) vs. Lower WBC/TP ratio was evaluated on In-hospital mortality (OR 9.64, 95% CI 3.20-29.07, p=<0.001). Each standard deviation increase in the white blood cell to total protein ratio (WBC/TP) was associated with an 8.64-fold increased risk of in-hospital mortality (OR 9.64) in infants with heart failure.
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