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June 27, 2026Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)Open Access

Construction of High Coverage Japanese Dental Pulp Cell Stock with Selective Genome Editing in the HLA Allele

Shuhei Arimoto Tomoko Kawaguchi Jyunichi Tatsumi Ken-ichi Tezuka

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Key Points

The research aims to create a dental pulp cell stock that covers HLA allele variations in the Japanese population for better transplant compatibility.
Utilized selective genome editing techniques on HLA alleles in dental pulp cells.
Focused on creating a high-coverage cell stock for potential transplant recipients.
Analyzed the prevalence of homozygous HLA haplotypes among Japanese donors.
Successfully constructed a dental pulp cell stock covering diverse HLA alleles.
Addressed the low occurrence of homozygous HLA haplotypes, previously less than 1 in 100.
Enhanced transplantation compatibility for a broader segment of the Japanese population.

Implication

Constructs a cell stock to improve transplantation compatibility in the Japanese population using genetic editing.

Abstract

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Cite This Study

Arimoto et al. (2026) studied this question.

synapsesocial.com/papers/6a435c08759b888809a5291c https://doi.org/10.2329/perio.68.59

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