Key result
The earliest detectable event of FMDV infection in pigs was primary infection in the lingual and paraepiglottic tonsils at 6 hours post inoculation, identifying the paraepiglottic tonsils as the primary site of infection.
The paraepiglottic tonsils are the primary site of FMDV infection in pigs exposed via the gastrointestinal tract, serving as the major source of viral shedding.
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May guide early diagnostic targeting in swine; leaves open transmission dynamics for prospective validation.
Stenfeldt et al. (2014) studied Foot-and-Mouth Disease (n=19). Intra-oropharyngeal inoculation or contact exposure with FMDV A24 Cruzeiro was evaluated on Detection of primary site of FMDV infection. The earliest detectable event of FMDV infection in pigs was primary infection in the lingual and paraepiglottic tonsils at 6 hours post inoculation, identifying the paraepiglottic tonsils as the primary site of infection.
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