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Review synthesizes knowledge on prostatic club cells, their functions, and implications for histopathologists.
). This review provides a comprehensive synthesis of current knowledge regarding prostatic Cc and Cc-phenotype conversion across prostate disease. Prostatic Cc possesses anti-inflammatory, regenerative, and immunoregulatory potential, and exhibits features like those of their pulmonary counterparts. Their ontogenesis, localization across different prostatic zones, gene expression profile, and histo-functional morphology are discussed and illustrated immunohistochemically using original material from the authors. Pathophysiological and morphogenetic considerations are also presented.
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Dikov et al. (2026) studied this question.
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