What question did this study set out to answer?

The aim is to understand how controlling the translation of autophagy genes affects cells' responses to genotoxic stress, specifically from hydroxyurea.

July 1, 2026

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Translation control of autophagy genes modulates cellular response to hydroxyurea-induced genotoxic stress

GMGayatri MohananIndian Institute of Science Bangalore KNKumkum NagIndian Institute of Science Bangalore HSH G SengerIndian Institute of Science Bangalore

Key Points

The aim is to understand how controlling the translation of autophagy genes affects cells' responses to genotoxic stress, specifically from hydroxyurea.
Evaluated cellular responses using hydroxyurea as a genotoxin
Assessed the role of autophagy genes in the DNA damage response
Utilized various inhibitors to determine effects on translation control
Cells with modulated autophagy gene translation showed enhanced DNA damage response.
They demonstrated improved survival rates under hydroxyurea treatment compared to control conditions.

Abstract

: CHX: cycloheximide; CPT: camptothecin; DDR: DNA damage response; GTA: genotoxin-associated targeted autophagy; HR: homologous recombination; HU: hydroxyurea; MMS: methyl methanesulfonate; mRNPs: mRNA-protein complexes; NHEJ: non-homologous end joining; P-bodies: processing bodies; RBPs: RNA binding proteins.

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Cite This Study

Mohanan et al. (Mon,) studied this question.

synapsesocial.com/papers/6a44ada75cd2549c8bc4325d https://doi.org/https://doi.org/10.1080/15548627.2026.2694657

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