Formulation and Evaluation of a Polyherbal Emulgel for Dual Therapeutic Activity in Inflammation Control and Wound Healing

Inflammation is an essential early phase of wound healing, but excessive or prolonged inflammation can impair granulation, re-epithelialization, and remodeling.[1,9] In chronic or infected wounds, oxidative stress and microbial burden further compromise repair, which is why modern wound therapies increasingly aim to combine anti-inflammatory, antioxidant, and antimicrobial effects in one formulation.[5,10] Wound healing is a coordinated biological process involving inflammation, proliferation, and remodeling, and persistent inflammation can delay tissue repair.[1] Topical delivery is highly suitable for local inflammatory and wound conditions because it can concentrate actives at the target site while reducing systemic exposure.[2] Emulgel is an advantageous semisolid system because it combines the solubilizing capacity of an emulsion with the favorable spreadability and patient acceptability of gel.[3] Polyherbal therapy is especially relevant in wound management because multiple phytoconstituents may act synergistically through anti-inflammatory, antioxidant, antimicrobial, and tissue-repair pathways.[4,5]