Key result
Higher systemic inflammation index and uric acid linked to severe CAD in chronic AF.
Why the study?
Inflammation is important in both AF and CAD, but the relationship between the systemic inflammation index, left ventricular functions, and CAD prevalence in chronic AF patients needed clarification.
Do systemic inflammation markers correlate with left ventricular dysfunction and coronary artery disease severity in patients with chronic atrial fibrillation?
Observational (n=572)
No
Do systemic inflammation markers correlate with left ventricular dysfunction and coronary artery disease severity in patients with chronic atrial fibrillation?
Systemic inflammation markers, particularly the systemic inflammation index and neutrophil-lymphocyte ratio, are associated with greater coronary artery disease severity, left ventricular dilation, and mortality in patients with chronic atrial fibrillation.
These observational links in AF should not change practice; leaves open inflammation's prognostic role.
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Çiriş et al. (2026) conducted an observational in Chronic Atrial Fibrillation (n=572). Systemic inflammation index (SII) vs. Lower systemic inflammation index was evaluated on Prevalence of CAD (SYNTAX score ≥23) and left ventricular functions. Increased systemic inflammation index and uric acid were associated with an increased risk of severe coronary artery disease (SYNTAX score ≥23) in patients with chronic atrial fibrillation.
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