Prognostic impact of 18F-fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance-proven cardiac involvement in pulmonary sarcoidosis: a single centre long-term cohort study
Long-term cohort study reveals that cardiac involvement worsens survival in patients with pulmonary sarcoidosis, indicating the need for careful monitoring.
Key Points
This study aims to evaluate the relationship between cardiac involvement and survival outcomes in pulmonary sarcoidosis patients.
Retrospective analysis of patients with histologically confirmed pulmonary sarcoidosis.
Cardiac involvement diagnosed through 18F-fluorodeoxyglucose positron emission tomography and cardiac magnetic resonance imaging.
Survival rates assessed over a median follow-up of 6.7 years.
3-, 5-, and 10-year survival rates were 98.2%, 97.0%, and 94.6%, respectively.
Cardiac involvement was found in 48 patients (9.4%), associated with increased all-cause mortality (age-adjusted HR 3.55, 95% CI 1.18–10.6; sex-adjusted HR 3.79, 95% CI 1.28–11.2).
Leading cause of death was malignancy (48%), with cardiac death and respiratory failure each accounting for 14%.