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July 1, 2026Open Access

Long-term in vivo CRISPR/Cas9 gene editing in liver triggers host immunity and clonal mutations in DNA Repair Genes

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Authors

曹C曹天埼(Tianqi Cao)

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Overview

Randomized trial uncovers immune response and genetic mutations from long-term CRISPR/Cas9 editing in liver, suggesting risks of genomic instability.

Key Points

  • This research aims to investigate the effects of long-term CRISPR/Cas9 gene editing on liver immunity and genomic stability.
  • Used mouse models for in vivo genome editing with CRISPR/Cas9.
  • Conducted transcriptomic analyses to assess apoptotic pathway suppression.
  • Performed whole-exome sequencing to identify mutations and chromosomal translocations.
  • Identified a chronic inflammatory microenvironment in the liver due to sustained editing.
  • Observed enrichment of nonsynonymous mutations in DNA repair genes, albeit at low frequency.
  • Detected increased rates of chromosomal translocations in heavily edited individuals.

Cite This Study

曹天埼(Tianqi Cao) (2026) studied this question.

synapsesocial.com/papers/6a44ae8c5cd2549c8bc43c80https://doi.org/10.26036/cnp0008752
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