Randomized-controlled trial of sacubitril/valsartan and amlodipine combination in Japanese uncontrolled hypertensive patients (J-SAMIT)

Figures

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  In this multicenter, randomized, double-blind, parallel group, active controlled trial, sacubitril/valsartan and amlodipine combination therapy showed dose-dependent reductions in office and 24-hour systolic blood pressure and a favourable safety profile in Japanese patients inadequately controlled on sacubitril/valsartan monotherapy, supporting its efficacy and safety as a treatment option

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  Fig. 1. Efficacy results for office trough BP in the morning in terms of (A) change from baseline at Week 8 in msSBP and msDBP, (B) msSBP of observed values by visit up to Week 8, and (C) proportion of patients achieving the defined BP level at Week 8

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  Fig. 2. Efficacy results for ambulatory BP in terms of (A) change from baseline at Week 8 in maSBP and maDBP, (B) post-dosing hourly maSBP, (C) change from baseline at Week 8 in daytime, nighttime, and morning maSBP at Week 8, and (D) proportion of patients achieving BP control during daytime (SBP/DBP < 135/85 mmHg), nighttime (SBP/DBP < 120/70 mmHg) and morning (SBP/DBP < 135/85 mmHg). Note: For parts (C) and (D), a participant’s daytime mean was the average from self-reported time of waking to self-reported time of falling asleep; the nighttime mean was the average from the time of falling asleep to the time of waking; and the morning mean was the average within 2 h from the time of waking

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  Fig. 3. Forest plot of change from baseline at Week 8 in msSBP by subgroup in (A) SacVal/AML 200 mg/10 mg, (B) SacVal/AML 200 mg/5 mg, and (C) SacVal/AML 200 mg/2.5 mg arms

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  Fig. 4. Waterfall plot change from baseline at Week 8 in (A) trough msSBP in the morning (B) maSBP during daytime, nighttime and morning. Note: A participant’s daytime mean was the average from self-reported time of waking to self-reported time of falling asleep; the nighttime mean was the average from the time of falling asleep to the time of waking; and the morning mean was the average within 2 h from the time of waking