November 12, 2004European Heart Journal
Classification and mechanism of initiation in patients with congenital long QT syndrome
Key result
Three predominant initiating modes of Torsade de Pointes were identified in congenital LQTS: short-long-short (65%), increased sinus rate (25%), and changed depolarization (10%).
Population
24 patients with congenital long QT syndrome with 111 episodes of Torsade de Pointes recorded on…
Design
Case_series
Authors
Discussion
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Member takes
Implication
TdP pattern recognition may refine monitoring in congenital LQTS; leaves open whether mechanism-specific interventions improve outcomes.
Study Design
Type
Observational (n=24)
Structured PICO
P
Population
24 patients with congenital long QT syndrome and 111 recorded episodes of Torsade de Pointes.
O
Outcome
Initiating mode of Torsade de Pointes (TdP), including preceding RR intervals, timing of initiating premature ventricular contraction (PVC), and cycle length of TdPsurrogate
In patients with congenital long QT syndrome, Torsade de Pointes initiates via three distinct patterns (short-long-short, increased sinus rate, and changed depolarization), suggesting different underlying arrhythmogenic mechanisms.
Cite This Study
Noda et al. (2004) conducted an observational in Congenital long QT syndrome (LQTS) (n=24). Initiating patterns of Torsade de Pointes was evaluated on Initiating mode, preceding RR intervals, timing of premature ventricular contraction, and cycle length of TdP. Three predominant initiating modes of Torsade de Pointes were identified in congenital LQTS: short-long-short (65%), increased sinus rate (25%), and changed depolarization (10%).