In patients with CKD and chronic systolic heart failure, beta-blocker treatment reduced the risk of all-cause mortality compared with placebo (RR 0.72; 95% CI 0.64 to 0.80).
Systematic Review (n=6,949)
Do beta-blockers reduce mortality in patients with chronic kidney disease stages 3 to 5?
Beta-blockers significantly reduce all-cause and cardiovascular mortality in patients with chronic kidney disease and chronic systolic heart failure, though they increase the risk of bradycardia and hypotension.
Relative Risk: 0.72 (95% CI 0.64–0.8)
OBJECTIVES: The aim of this systematic review was to study the benefits and risks of beta-adrenergic antagonists (beta-blockers) in patients with chronic kidney disease (CKD). BACKGROUND: There is an excess burden of cardiovascular disease and death in people with CKD. Despite their potential benefits, the effects of beta-blockers in this population are uncertain. METHODS: CENTRAL (Cochrane Central Register of Controlled Trials), Medline (Medical Literature Analysis and Retrieval System Online), and Embase (Excerpta Medical Database) were searched for randomized controlled trials with at least 3 months of follow-up in patients with CKD stages 3 to 5 that reported mortality outcomes. Summary estimates of effect were obtained using a random effects model. RESULTS: Eight trials met criteria for review: 6 placebo-controlled trials involving 5,972 participants with chronic systolic heart failure and 2 angiotensin-converting enzyme inhibitor-comparator trials involving 977 participants not known to have heart failure. In CKD patients with heart failure, compared with placebo, beta-blocker treatment reduced the risk of all-cause (risk ratio RR: 0.72, 95% confidence interval CI: 0.64 to 0.80) and cardiovascular mortality (RR: 0.66, 95% CI: 0.49 to 0.89), but increased the risk of bradycardia (RR: 4.92, 95% CI: 3.20 to 7.55) and hypotension (RR: 5.08, 95% CI: 3.48 to 7.41). Quantitative meta-analysis was not performed for the non-heart failure studies due to substantial clinical diversity or lack of informative data. CONCLUSIONS: Treatment with beta-blockers improved all-cause mortality in patients with CKD and chronic systolic heart failure. There is insufficient evidence to conclude whether people with CKD who are not known to have heart failure derive benefit from beta-blockers.
“This systematic review based on six placebo-controlled trials concluded that treatment with beta-blockers improved all-cause mortality in patients with chronic kidney disease (CKD) and chronic systolic heart failure. In CKD patients with systolic heart failure, compared with placebo, beta-blocker treatment reduced the risk of all-cause (risk ratio [RR]: 0.72; 95% confidence interval [CI]: 0.64 to 0.80) and cardiovascular mortality (RR: 0.66; 95% CI: 0.49 to 0.89) but increased the risk of bradycardia (RR: 4.92; 95% CI: 3.20 to 7.55) and hypotension (RR: 5.08; 95% CI: 3.48 to 7.41). However, there is insufficient evidence to determine whether beta-blockers may incur similar benefits in CKD patients without systolic heart failure.”
Badve et al. (Wed,) conducted a systematic review in Chronic kidney disease (CKD) (n=6,949). Beta-adrenergic antagonists (beta-blockers) vs. Placebo or angiotensin-converting enzyme inhibitor was evaluated on All-cause mortality (RR 0.72, 95% CI 0.64 to 0.80). In patients with CKD and chronic systolic heart failure, beta-blocker treatment reduced the risk of all-cause mortality compared with placebo (RR 0.72; 95% CI 0.64 to 0.80).