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Review details the mitochondrial calcium uniporter's role in signaling networks, highlighting advances in regulatory mechanisms and pharmacological targeting.
fluxes and revealed its pivotal role in health and disease. Here, we retrace the trajectory of the field from the pioneering observations of the 1960s to the molecular era of the MCUC, emphasizing the latest advances in its regulation, integration into cellular networks, and pharmacological targeting.
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Herran et al. (2026) studied this question.
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