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Experimental findings reveal that isoschaftoside inhibits osteoclastogenesis in vitro by suppressing key signaling pathways.
has traditionally been used to manage inflammation-related diseases, and its crude extracts have demonstrated pharmacological effects. Nonetheless, the influence of ISH on osteoclastogenesis has not been documented previously. In this study, we explored the effect of ISH on osteoclastogenesis. Our findings indicate that ISH attenuates RANKL-induced activation of NF-κB and MAPK; moreover, ISH inhibits osteoclastogenesis and bone resorption stimulated by RANKL and M-CSF.
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Yun et al. (2026) studied this question.
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