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July 2, 2026Nature CommunicationsOpen Access

Unified bilayer membranes with mechanically reinforced interface for stage-adaptive bone regeneration

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Authors

DYDu YNingbo UniversityYNYangyi NieChinese Academy of SciencesZLZhiheng LuoGuangdong Technion-Israel Institute of Technology

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Implication

Randomized trial demonstrates enhanced bone regeneration in a rat model using advanced bilayer membranes, indicating improved healing outcomes.

Key Points

  • The aim is to develop a reinforced bilayer membrane to improve bone regeneration through better interfacial integration and stability.
  • Developed a unified bilayer membrane with a reinforced dual-crosslinking interface.
  • Tested the membrane in a rat critical-sized cranial defect model over an 8-week period.
  • Evaluated mechanical strength and various biological functions related to bone healing.
  • Achieved ~2.7-fold greater bone volume regeneration compared to clinical collagen membranes after 8 weeks.
  • Demonstrated superior mechanical strength of ~156 MPa dry and ~8.6 MPa wet.
  • Regulated multiple biological functions including antibacterial, immunomodulation, neurovascularization, and osteogenesis.

Cite This Study

Y et al. (2026) studied this question.

synapsesocial.com/papers/6a46015f9ed134303131124ehttps://doi.org/10.1038/s41467-026-74932-x
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