On-Cell Detection of Polysaccharide One-Bond ¹ J CH Couplings by Proton-Detected Solid-State NMR

Alons Lends; Gaëlle Lamon; Alicia Vallet; Axelle Grélard; Estelle Morvan; Vishukumar Aimanianda; Paul Schanda; Antoine Loquet

doi:10.1021/jacs.6c06064

June 30, 2026Journal of the American Chemical Society

On-Cell Detection of Polysaccharide One-Bond ¹ J CH Couplings by Proton-Detected Solid-State NMR

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Key Points

Determine the coupling constants and native configurations of polysaccharide units in Cryptococcus.
Utilized high-resolution proton-detected solid-state NMR techniques.
Analyzed five mobile polysaccharide units of the cryptococcal capsule.
Identified coupling constants for five polysaccharide units.
Confirmed native configurations consistent with previous solution NMR-based assignments.

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Implication

High-resolution NMR identifies mobilities in polysaccharides, confirming structural configurations.

Abstract

. High-resolution proton-detected spectra enabled the determination of coupling constants for five mobile polysaccharide units of the cryptococcal capsule, revealing their native configurations and confirming previous solution NMR-based anomeric configuration assignments.

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Lends et al. (2026) studied this question.

synapsesocial.com/papers/6a4601a99ed1343031311643 https://doi.org/10.1021/jacs.6c06064

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On-Cell Detection of Polysaccharide One-Bond ¹ J CH Couplings by Proton-Detected Solid-State NMR

Key Points

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Implication

Abstract

Discussion

Cite This Study

On-Cell Detection of Polysaccharide One-Bond ¹ J CH Couplings by Proton-Detected Solid-State NMR

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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