Review highlights biological functions of inclusion membrane proteins in Chlamydia trachomatis interactions with host cells, indicating implications for understanding pathogenic mechanisms.
Chlamydia trachomatis is an obligate intracellular prokaryote. During the process of infecting host cells, C. trachomatis forms a unique inclusion structure, which serves as a critical niche for the survival and replication of C. trachomatis within host cells. The inclusion membrane is composed of various inclusion membrane proteins (Inc proteins), which play a pivotal role in the interaction between C. trachomatis and host cells. This review illustrates functional research progress of C. trachomatis Inc proteins and their molecular interactions with host cells, facilitating deeper understanding of chlamydial pathogenic mechanisms.
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Guo et al. (2026) studied this question.
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