Key result
Higher sarcopenic obesity index linked to ~31% greater risk of incident heart failure and mortality.
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Why the study?
Assessing sarcopenic obesity may clarify the complex prognostic value of obesity in cardiovascular disease, but quantifying sarcopenia in clinical practice remains challenging.
Does a higher imaging-derived sarcopenic obesity index predict incident heart failure, cardiovascular death, and all-cause mortality?
Cohort (n=55,768)
Does a higher imaging-derived sarcopenic obesity index predict incident heart failure, cardiovascular death, and all-cause mortality?
Hazard Ratio: 1.31 (95% CI 1.16–1.49)
An imaging-derived sarcopenic obesity index is associated with adverse cardiac remodeling, incident heart failure, and mortality, establishing it as a clinically meaningful cardiovascular risk phenotype.
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“[Sarcopenic obesity] is emerging as a systemic cardiometabolic phenotype linking ageing, impaired muscle biology, heart failure vulnerability and frailty. By enabling scalable opportunistic quantification of muscle mass from routine CMR, Sanghvi et al., provide proof of concept that deep learning...”
“"[Sarcopenic obesity] is emerging as a systemic cardiometabolic phenotype linking ageing, impaired muscle biology, heart failure vulnerability and frailty."”
“"These results highlight a potential application of the sarcopenic obesity index as a biomarker for nominating individuals in whom targeted therapies that preserve or augment muscle mass, while reducing adiposity, may be of greatest utility."”
Sarcopenic obesity indexing on routine CMR may refine risk stratification; leaves open whether targeting it improves outcomes.
BACKGROUND: The prognostic value of obesity in cardiovascular disease is complex. Measures such as body mass index and waist-to-height ratio show differing associations with outcomes, especially in heart failure. Assessing sarcopenic obesity, the coexistence of excess fat and low muscle mass, may clarify this relationship; however, quantifying sarcopenia in clinical practice remains challenging. OBJECTIVES: The goal was to establish a translatable method of assessing sarcopenic obesity from cardiovascular imaging and assess its clinical relevance using long-term follow-up, genomic, and transcriptomic data. METHODS: We developed a deep learning pipeline to quantify pectoralis major muscle mass from 55,768 cardiovascular magnetic resonance examinations and combined this with body weight to derive a novel sarcopenic obesity index. Associations with cardiac remodeling phenotypes and adverse cardiovascular and mortality outcomes were tested in multivariable models. Genome-wide association analysis, colocalization, and polygenic risk score evaluation were performed for the sarcopenic obesity index. Transcriptomic profiling of skeletal muscle across 7 pathophysiological states assessed differential gene expression. RESULTS: A higher sarcopenic obesity index was associated with adverse cardiac remodeling, and with increased risk of incident heart failure (HR: 1.31; 95% CI: 1.16-1.49), cardiovascular death (HR: 1.51; 95% CI: 1.25-1.81), and all-cause mortality (HR: 1.37; 95% CI: 1.26-1.49). Genome-wide association analysis identified 16 loci for sarcopenic obesity. Loci included genes associated with heart failure and nonischemic cardiomyopathy, with colocalization implicating shared causal variants in heart failure. Transcriptomic profiling demonstrated that sarcopenic obesity loci were specifically modulated during muscle atrophy. Analyses identified ACVR2B, the target of bimagrumab, which is being tested with semaglutide to enhance fat loss while maintaining lean mass. CONCLUSIONS: These results establish sarcopenic obesity as a clinically meaningful cardiovascular risk phenotype and point to viable therapeutic targets.
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Sanghvi et al. (2026) conducted a cohort in Cardiovascular disease (n=55,768). Higher sarcopenic obesity index vs. Lower sarcopenic obesity index was evaluated on Incident heart failure (HR 1.31, 95% CI 1.16-1.49). A higher sarcopenic obesity index was associated with increased risk of incident heart failure (HR 1.31; 95% CI 1.16-1.49), cardiovascular death, and all-cause mortality.
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