Key result
Non-atherosclerotic SCAD predominantly affects young women and is linked to FMD and pregnancy.
Why the study?
Demarcating acute SCAD from coronary atherothrombosis and determining the proper therapeutic approach remains a major clinical challenge, with variable triggers and often unknown causes.
This review highlights the pathophysiology of SCAD, emphasizing the role of hematoma rather than thrombus, and outlines current therapeutic approaches.
Supports heightened awareness of SCAD in young women with ACS; leaves open optimal management and trigger identification.
Spontaneous coronary artery dissection (SCAD) accounts for 1.7%-4% of all acute coronary syndrome presentations, particularly among young women with an emerging awareness of its importance. The demarcation of acute SCAD from coronary atherothrombosis and the proper therapeutic approach still represents a major clinical challenge. Certain arteriopathies and triggers are related to SCAD, with high variability in their prevalence, and often, the cause remains unknown. The objective of this review is to provide contemporary knowledge of the pathophysiology of SCAD and possible therapeutic solutions.
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Djoković et al. (2023) conducted a review in Spontaneous coronary artery dissection (SCAD). Spontaneous coronary artery dissection is a distinct non-atherosclerotic condition predominantly affecting young women, characterized by intramural hematoma formation and associated with fibromuscular dysplasia and pregnancy.
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