Young Investigator Award 2026: Extent and incidence of pseudo-worsening of kidney function due to oral antitumor therapeutics in the AMBORA cohort: an analysis of real-world data

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Oral antitumor therapeutics lead to a quantifiable incidence of pseudo-worsening of kidney function in real-world patient cohorts due to the inhibition of renal creatinine transporters. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Michael I. Sponfeldner

doi:10.1007/s00210-026-05651-9

July 1, 2026Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Young Investigator Award 2026: Extent and incidence of pseudo-worsening of kidney function due to oral antitumor therapeutics in the AMBORA cohort: an analysis of real-world data

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Key Points

To evaluate how oral antitumor therapeutics affect kidney function, particularly focusing on pseudo-worsening.
Analyzed data from the AMBORA cohort regarding kidney function during OAT treatment.
Monitored serum creatinine levels and estimated glomerular filtration rates (eGFR SCr).
Investigated the inhibition of renal transport proteins by various OATs.
Increased serum creatinine levels were observed without accompanying kidney injury as assessed by alternative methods.
Changes in eGFR SCr were attributed to the inhibition of renal creatinine transporters by OATs.

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Implication

Analyzes kidney function changes due to oral antitumor therapeutics in oncology, suggesting monitoring strategies.

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Michael I. Sponfeldner (2026) studied this question.

synapsesocial.com/papers/6a4750f45c29257aa257875c https://doi.org/10.1007/s00210-026-05651-9

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Young Investigator Award 2026: Extent and incidence of pseudo-worsening of kidney function due to oral antitumor therapeutics in the AMBORA cohort: an analysis of real-world data

Key Points

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Implication

Discussion

Cite This Study

Young Investigator Award 2026: Extent and incidence of pseudo-worsening of kidney function due to oral antitumor therapeutics in the AMBORA cohort: an analysis of real-world data

Key Points

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