FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy

Xu Cao; H Yu; R Soliman; Pei Ying; S. Zhang; Li Liang

doi:10.1007/s12105-026-01947-7

June 30, 2026Head and Neck PathologyOpen Access

FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy

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Key Points

This research aims to identify and analyze genomic alterations in HPV-associated sinonasal squamous cell carcinoma (SNSCC).
Reported a case of HPV-associated SNSCC with FGFR3::TACC3 fusion and NOTCH1 mutation.
Focused on distinguishing HPV-associated SNSCC from other tumor types via genomic analysis.
Utilized limited biopsy specimens to confirm molecular alterations.
FGFR3::TACC3 fusion detected in the reported SNSCC case.
NOTCH1 mutation identified as a significant genomic alteration.
Findings suggest potential for targeted therapy in managing HPV-associated SNSCC.

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Implication

Case report identifies FGFR3::TACC3 fusion and NOTCH1 mutation in HPV-associated carcinoma, highlighting diagnostic challenges and therapeutic implications.

Abstract

Sinonasal squamous cell carcinoma (SNSCC) comprises a heterogeneous group of tumors with emerging molecular subtypes. Human papillomavirus (HPV)-associated SNSCC is a distinct entity, although actionable genomic alterations beyond HPV-driven pathways remain underexplored. Distinguishing HPV-associated SNSCC from carcinoma ex inverted papilloma can be particularly challenging in limited biopsy specimens, as these lesions may appear morphologically similar. We report a case of HPV-associated SNSCC with concurrent FGFR3::TACC3 fusion and NOTCH1 p.C1416 stop-gain mutation.

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Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a47513c5c29257aa257898d https://doi.org/10.1007/s12105-026-01947-7

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FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy

Key Points

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Abstract

Discussion

Cite This Study

FGFR3::TACC3 Fusion and NOTCH1 Loss-of-Function in a Case of HPV-Associated Sinonasal Squamous Cell Carcinoma: Diagnostic Challenge and Implications for Targeted Therapy

Key Points

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Abstract

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