Demonstrates how sequence-structure relationships influence folding in oligomers, suggesting important design implications.
, which showed strong positive cooperativity is consistent with a hexagonal grid model for the conformation of the backbone. These sequence-structure relationships show that favorable folding motifs arise when the positions of complementary recognition sites align with the conformational preferences of the triazine-piperazine backbone.
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Cotirlan et al. (2026) studied this question.
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