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July 3, 2026International Archives of Allergy and Immunology

Differences in Reported Anaphylaxis Associated With Common Nonsteroidal Anti-inflammatory Drugs: A Pharmacovigilance Study

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Authors

SLSuwei LiuHYHaoyang YuYWYuxin Wu

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Overview

Pharmacovigilance study characterizes anaphylaxis reporting for NSAIDs, indicating notable drug-specific differences.

Key Points

  • The aim is to analyze reporting patterns of anaphylaxis associated with NSAIDs and identify disproportionality signals.
  • Cross sectional analysis of FAERS reports from 2015Q1 to 2025Q2
  • Included five NSAIDs: ibuprofen, diclofenac, naproxen, celecoxib, and meloxicam
  • Disproportionality assessed using reporting odds ratio and empirical Bayes geometric mean.
  • Total adverse event reports: 51,837 for ibuprofen, 43,979 for diclofenac, 27,043 for naproxen, 13,085 for celecoxib, and 2,591 for meloxicam
  • Anaphylaxis reports were 938 (1.81%) for ibuprofen and 919 (2.09%) for diclofenac, showing disproportionality signals for all NSAIDs
  • Female predominance and age variations were noted across NSAIDs.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a4754f05c29257aa257a4f2https://doi.org/10.1159/000552828
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