Taraxasterol Exerts Cytoprotective Effects Against Nicotine Toxicity in Leydig (TM3) and Sertoli (TM4) Cell Lines

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This research aims to determine whether taraxasterol can protect Leydig and Sertoli cells from nicotine-induced toxicity.
TM3/4 cells were treated with taraxasterol extract for 24 hours before exposure to nicotine for 24 hours.
Cell viability was assessed using the MTT assay and oxidative stress biomarkers were measured with commercial kits.
Gene expression analysis and apoptosis assessment were performed alongside statistical analysis using ANOVA and Tukey's test.
Taraxasterol significantly improved cell viability compared to nicotine alone (exact quantification not provided).
Marked reductions in oxidative stress biomarkers (MDA, GSH, ROS) were observed with taraxasterol treatment (details not specified).
Increased survival rates and decreased apoptosis levels were linked to taraxasterol intervention (exact metrics not detailed).

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Evaluates taraxasterol's protective effects against nicotine toxicity in cell lines, suggesting potential benefits for male reproductive health.

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Hashempour et al. (2026) studied this question.

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