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Review highlights cryogel engineering for stem cell and biomolecule delivery in osteoarthritis, indicating potential advancements in treatment.
Osteoarthritis (OA) is a leading cause of chronic pain and disability, and lacks disease-modifying therapies. Unlike conventional hydrogels, which suffer from poor mechanical robustness and limited retention, cryogels overcome existing limitations through their interconnected pore architecture, shape-memory behavior, and fatigue-resistant mechanics. Here, we review how cryogels are being engineered as platforms for stem cell delivery, bioactive molecule release, localized gene activation, and immunomodulation, and discuss key translation challenges.
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Durant et al. (2026) studied this question.
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