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This research introduces a metal-free method for enhancing the functionalization of alkynes through a novel reaction system.

Metal‐Free Multifunctionalization of Alkynes Promoted by Acid and Selectfluor

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Randomized trial demonstrates efficient tetrafunctionalization of alkynes, suggesting a new synthetic approach.

This research introduces a metal-free method for enhancing the functionalization of alkynes through a novel reaction system.
Utilized an acid/Selectfluor system for tetrafunctionalization of internal alkynes.
Conducted gram-scale synthesis to assess practical utility and efficiency.
Performed mechanistic studies to verify the reaction pathway and amide group origin.
Achieved the formation of four new chemical bonds (C─F, C─C, and C─N) in a single step.
Confirmed the method's efficiency under mild conditions with a deuterium kinetic isotope effect observed.
Established a transition-metal-free pathway, providing a complementary synthetic option.

Wu et al. (2026) studied this question.

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View Full Paper

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Authors

Randomized trial demonstrates efficient tetrafunctionalization of alkynes, suggesting a new synthetic approach.

This research introduces a metal-free method for enhancing the functionalization of alkynes through a novel reaction system.
Utilized an acid/Selectfluor system for tetrafunctionalization of internal alkynes.
Conducted gram-scale synthesis to assess practical utility and efficiency.
Performed mechanistic studies to verify the reaction pathway and amide group origin.
Achieved the formation of four new chemical bonds (C─F, C─C, and C─N) in a single step.
Confirmed the method's efficiency under mild conditions with a deuterium kinetic isotope effect observed.
Established a transition-metal-free pathway, providing a complementary synthetic option.

Wu et al. (2026) studied this question.

View Full Paper

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Bookmark