Right ventromedial prefrontal lesions result in paradoxical cardiovascular activation with emotional stimuli
Key result
Right-sided ventromedial prefrontal cortex lesions resulted in paradoxical significant increases in heart rate and blood pressure during pleasant visual stimulation compared to healthy volunteers.
Why the study?
Do unilateral ventromedial prefrontal cortex lesions alter autonomic cardiovascular responses to emotional visual stimuli?
Population
26 participants, including 6 patients with left-sided ventromedial prefrontal cortex lesions, 7 patients…
Comparison
Exposure to non-stressful neutral, pleasant, and… vs Healthy volunteers and baseline resting state.
Design
Cross-sectional
Authors
Discussion
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Implication
Right VMPFC lesions may heighten cardiovascular reactivity to pleasant stimuli; leaves open hemispheric specialization in autonomic emotional regulation.
Study Design
Type
Observational (n=26)
Structured PICO
Do unilateral ventromedial prefrontal cortex lesions alter autonomic cardiovascular responses to emotional visual stimuli?
P
Population
26 participants, comprising 13 patients with unilateral ventromedial prefrontal cortex lesions and 13 healthy volunteers, evaluated for autonomic responses to emotional visual stimuli.
E
Exposure
Exposure to non-stressful neutral, pleasant, and unpleasant visual stimulation (VES) via emotionally laden slides.
C
Comparator
Healthy volunteers and baseline resting state.
O
Outcome
Heart rate (HR) as R-R interval (RRI) and blood pressure (BP) responses to visual stimulation.surrogate
Right ventromedial prefrontal cortex lesions result in paradoxical sympathetic activation during emotional visual stimulation, suggesting hemispheric specialization in autonomic modulation.
Cite This Study
Hilz et al. (2006) conducted an observational in Unilateral ventromedial prefrontal cortex lesions (n=26). Unilateral ventromedial prefrontal cortex lesions vs. Healthy volunteers was evaluated on Heart rate and blood pressure responses to non-stressful emotional visual stimulation. Right-sided ventromedial prefrontal cortex lesions resulted in paradoxical significant increases in heart rate and blood pressure during pleasant visual stimulation compared to healthy volunteers.