Key result
At 10 microM, arachidonic acid and docosahexaenoic acid blocked HERG channels to a similar extent (37.7% vs. 50.2%, P>0.05), shifting activation and inactivation curves.
Absolute Event Rate: 37.7% vs 50.2%
p-value: p=> 0.05
Omega-3 and omega-6 polyunsaturated fatty acids block HERG channels in a time-, voltage-, and use-dependent manner, suggesting they bind preferentially to the open state of the channel.
No takes yet. Share an insight, caveat, or question.
May modulate cardiac repolarization via PUFAs; leaves open in vivo arrhythmia relevance and dietary implications.
Guizy et al. (2005) studied this question. Arachidonic acid (AA) and docosahexaenoic acid (DHA) was evaluated on Blockade of HERG channels at the end of 5-s pulses to -10 mV (p=> 0.05). At 10 microM, arachidonic acid and docosahexaenoic acid blocked HERG channels to a similar extent (37.7% vs. 50.2%, P>0.05), shifting activation and inactivation curves.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: