Key result
Pulse arrival time feature PAT Rb shows a moderate negative correlation with systolic blood pressure.
Why the study?
Many researchers using the MIMIC database assume signals are synchronized, prompting an investigation into pulse arrival time interval calculation and its usefulness for evaluating blood pressure.
Do pulse arrival time (PAT) features accurately correlate with and evaluate blood pressure in intensive care patients from the MIMIC database?
Observational (n=121)
Do pulse arrival time (PAT) features accurately correlate with and evaluate blood pressure in intensive care patients from the MIMIC database?
Effect estimate: r = -0.54
This study demonstrates that while pulse arrival time correlates moderately with blood pressure, researchers must verify signal synchronicity before using the MIMIC database for cuffless blood pressure algorithm development.
MIMIC synchronization issues caution against unverified PAT-BP correlations; leaves open reliable cuffless algorithms until data quality is confirmed.
Cardiovascular disease (CVD) is the number one cause of non-infectious morbidity and mortality in the world. The detection, measurement, and management of high blood pressure play an essential role in the prevention and control of CVDs. However, owing to the limitations and discomfort of traditional blood pressure (BP) detection techniques, many new cuff-less blood pressure approaches have been proposed and explored. Most of these involve arterial wave propagation theory, which is based on pulse arrival time (PAT), the time interval needed for a pulse wave to travel from the heart to some distal place on the body, such as the finger or earlobe. For this study, the Medical Information Mart for Intensive Care (MIMIC) database was used as a benchmark for PAT analysis. Many researchers who use the MIMIC database make the erroneous assumption that all the signals are synchronized. Therefore, we decided to investigate the calculation of PAT intervals in the MIMIC database and check its usefulness for evaluating BP. Our findings have important implications for the future use of the MIMIC database, especially for BP evaluation.
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Liang et al. (2019) conducted an observational in Intensive care patients (MIMIC database) (n=121). Pulse Arrival Time (PAT) features vs. Arterial blood pressure (ABP) reference was evaluated on Pearson correlation coefficient between PAT features (specifically PAT Rb) and systolic blood pressure (r = -0.54). Pulse arrival time feature PAT Rb showed a moderate negative correlation with systolic blood pressure (r = -0.54), highlighting challenges with signal synchronicity when using the MIMIC database.
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