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Shows effective Salmonella detection in spiked chicken samples, indicating improved pathogen monitoring methods.
Reliable pathogen detection in complex suspensions requires both effective sample handling and stable signal generation. Here, we report an acoustofluidic–magnetic relaxation biosensing (MRB) platform for Salmonella detection that combines acoustofluidic particle manipulation with oscillation-stabilized magnetic readout. A cylindrical-array region enhances encounters between Salmonella and immunomagnetic nanobeads (IMNBs) through convective mixing, while a butterfly-shaped acoustic streaming vortex (BSAV) region preferentially retains micron-scale Salmonella –IMNB complexes and generates a nanoscale-dominant outlet suspension. This outlet suspension is subsequently analyzed by an oscillation-assisted MRB system, in which axial micro-oscillation suppresses bead sedimentation and aggregation and stabilizes the ΔT 2 response. Under optimized conditions, the biosensor showed a linear response from 4.8 × 10 1 to 4.8 × 10 5 CFU/mL, with a limit of detection of 29 CFU/mL and a total assay time of approximately 40 min. The platform also exhibited good specificity and satisfactory recoveries of 92.68–103.95% in spiked chicken samples. The results demonstrate that acoustofluidic restructuring of suspension composition can support stable and quantitative magnetic relaxation detection in the Salmonella -spiked chicken model system.
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Duan et al. (2026) studied this question.
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