Role of E3 Ubiquitin Ligases in Oligodendrocyte Health and Disease

Protein ubiquitination is a type of posttranslational modification that occurs in all cells to regulate numerous biological processes. Ubiquitination of proteins is carried out by an enzymatic cascade where E3 ubiquitin ligases facilitate the final step in the transfer of ubiquitin to substrates. This review focuses on the role of E3 ubiquitin ligases in the regulation of oligodendrocytes, a glial cell type in the central nervous system that is critical for axon myelination and overall neuronal health. Here we focus on how protein ubiquitination dominantly driven by E3 ubiquitin ligase enzymes alters the development, maintenance, and disease pathogenesis in oligodendrocytes.