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Divergent three-component assembly generates complex dibenzofurans, suggesting a novel synthetic method.
-hydroxyphenyl propargylamines, pyridinium 1,4-zwitterionic thiolates, and nitroalkanes has been established for the rapid assembly of densely functionalized, non-symmetric tricyclic dibenzofuran frameworks. This step-economical strategy simultaneously constructs the central furan core, peripheral arene moiety, and two ester groups in a single operation. Notably, the reaction proceeds smoothly under ambient air conditions and employs undried nitroalkanes as both a C1 synthon and solvent. The protocol features mild conditions, a broad substrate scope, and excellent functional group compatibility. Moreover, its operational simplicity, scalability, and suitability for late-stage diversification underscore the synthetic utility of this methodology for complex molecular construction.
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Y et al. (2026) studied this question.
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