A Rare Case of Giant Facial Myoepithelioma: Diagnostic Approach and Treatment

Myoepithelioma is a rare benign tumor of the salivary glands, now recognized as a distinct nosological entity. This article presents the case of a large myoepithelioma that developed in the minor salivary glands of the cheek in a 53-year-old married man. The clinical appearance of the lesion, combined with its extension into the deep spaces of the face, initially suggested a malignant tumor. Biopsies performed on the mass suggested a pleomorphic adenoma, but microscopic and immunohistochemical analysis of the surgical specimen confirmed the myoepithelial origin of the tumor. However, the diagnosis of this type of neoplasm remains difficult due to the wide variability of its clinical, histological, and cytological characteristics. A good understanding of the morphological architectures and specific immunohistochemical profiles described in this study is essential for making an accurate diagnosis and avoiding misinterpretation.