Large-scale genomic profiling reveals distinct age-associated genomic architectures in osteosarcoma, indicating heterogeneity and future therapeutic implications.
Large‐scale genomic profiling reveals that osteosarcoma exhibits distinct age‐associated genomic architectures across pediatric, adolescent, and young adult patients. These findings support age as a biologically meaningful dimension of osteosarcoma heterogeneity and provide a framework for future molecular stratification and genome‐informed therapeutic development.
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Guo et al. (2026) studied this question.
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