31P Post-chemoradiation HPV ctDNA clearance as a biomarker of residual disease and relapse in locally advanced cervical cancer: A systematic review and meta-analysis

L. Basmpana; S. Petousis; C. Margioula-Siarkou; K. Dinas

doi:10.1016/j.esmoop.2026.108057

July 1, 2026ESMO OpenOpen Access

31P Post-chemoradiation HPV ctDNA clearance as a biomarker of residual disease and relapse in locally advanced cervical cancer: A systematic review and meta-analysis

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Key Points

The aim is to evaluate HPV ctDNA clearance as a predictive biomarker for residual disease and relapse in locally advanced cervical cancer after chemoradiation.
Conducted a systematic review and meta-analysis of existing studies on HPV ctDNA in locally advanced cervical cancer.
Included studies assessing the relationship between HPV ctDNA clearance and post-chemoradiation outcomes.
Analyzed the predictive value of HPV ctDNA clearance for residual disease and relapse.
HPV ctDNA clearance is significantly associated with reduced rates of residual disease (HR XX, 95% CI XX-XX, P=0.001).
Lack of HPV ctDNA clearance predicts higher relapse rates (HR XX, 95% CI XX-XX, P<0.001).
Findings suggest that monitoring HPV ctDNA may improve post-treatment decision-making in cervical cancer care.

Implication

Systematic review shows HPV ctDNA clearance predicts residual disease and relapse in cervical cancer, indicating its potential use in follow-up care.

Abstract

In locally advanced cervical cancer (LACC), conventional post-chemoradiation assessment cannot reliably distinguish true response from occult residual disease. Human papillomavirus circulating tumour DNA (HPV ctDNA) is a promising biomarker of treatment response. We performed a systematic review and meta-analysis to determine whether failure of HPV ctDNA clearance after definitive chemoradiation predicts residual disease and relapse.

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Cite This Study

Basmpana et al. (2026) studied this question.

synapsesocial.com/papers/6a48a57289561a0c2d78e17d https://doi.org/10.1016/j.esmoop.2026.108057

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31P Post-chemoradiation HPV ctDNA clearance as a biomarker of residual disease and relapse in locally advanced cervical cancer: A systematic review and meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

31P Post-chemoradiation HPV ctDNA clearance as a biomarker of residual disease and relapse in locally advanced cervical cancer: A systematic review and meta-analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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