Engineered Young Brown Adipose Tissue-Derived Exosomes Alleviate Radiation-Induced Lung Injury by Promoting G Protein-Coupled Receptor 183 Ubiquitination

) as a potential downstream target, showing upregulation after radiation but downregulation following BAT-exo@Au treatment. Further in vitro experiments demonstrated that BAT-exo@Au promoted the interaction between Gpr183 and the E3 ubiquitin ligase NEDD4, facilitating Gpr183 ubiquitination and proteasomal degradation. This study suggests that exosomes derived from young BAT may serve as a therapeutic strategy for the prevention of radiation-induced lung injury. In conclusion, BAT-exo@Au shows promise as a preventive approach for radiation-induced lung injury, potentially through modulation of Gpr183 via enhanced Gpr183-NEDD4 interaction and ubiquitination.