16P Integrative proteogenomics reveals survival-linked co-expression modules and an HR activity signature in high-grade serous ovarian cancer

B. Werner; A. Pandey; R. Saoud; L. Twomey; D. Ariyaratne; C. Kennedy; J. Hendley; L. Nguyen; G.L. Maxwell; B. Nelson; A. DeFazio; K. Alsop; T. P. Conrads; D. Bowtell; D.W. Garsed

doi:10.1016/j.esmoop.2026.108041

July 1, 2026ESMO OpenOpen Access

16P Integrative proteogenomics reveals survival-linked co-expression modules and an HR activity signature in high-grade serous ovarian cancer

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to identify prognostic biomarkers and therapeutic targets in high-grade serous ovarian cancer based on molecular characterisation.
Analyzed molecular data from high-grade serous ovarian cancer cases;
Focused on long-term and short-term survivors for comparative insights;
Integrated proteogenomic analysis to identify co-expression modules.
Identified several co-expression modules linked to survival duration;
Discovered a specific HR (homologous recombination) activity signature in subjects with better outcomes.

Implication

Uncovers survival-linked gene modules in ovarian cancer, suggesting new treatment targets.

Abstract

The molecular characterisation of high-grade serous ovarian cancer (HGSC) in exceptionally long- or short-term survivors has the potential to reveal novel prognostic biomarkers and clinically actionable targets.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Werner et al. (2026) studied this question.

synapsesocial.com/papers/6a48a72989561a0c2d78eac8 https://doi.org/10.1016/j.esmoop.2026.108041

View Full Paper

Ask AI

Bookmark

Share

16P Integrative proteogenomics reveals survival-linked co-expression modules and an HR activity signature in high-grade serous ovarian cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

16P Integrative proteogenomics reveals survival-linked co-expression modules and an HR activity signature in high-grade serous ovarian cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading