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Demonstrates efficient synthesis of capsular polysaccharides in Acinetobacter baumannii, suggesting a novel approach for oligosaccharide assembly.
Herein, we report a convergent 2 + 1 strategy for the synthesis of the Acinetobacter baumannii K91 and K25 CPS trisaccharide repeating units. A cellobiose-derived β-linked disaccharide donor bearing the requisite β-1,4-glycosidic framework enabled divergent assembly of both targets, while late-stage functional-group interconversions provided the β-ManNAcA-containing motifs. This route minimizes glycosylation steps and offers efficient access to structurally defined CPS oligosaccharides.
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Xue et al. (2026) studied this question.
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