What question did this study set out to answer?

This study aims to develop and validate a method for quantifying belumosudil concentrations in patients with chronic graft-versus-host disease.

Wide-Range Quantification of Belumosudil in Patients with Chronic Graft-Versus-Host Disease by High-Performance Liquid Chromatography

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Randomized trial quantifies belumosudil levels in patients with chronic graft-versus-host disease, suggesting improved therapeutic monitoring.

This study aims to develop and validate a method for quantifying belumosudil concentrations in patients with chronic graft-versus-host disease.
Extracted belumosudil from 50 µL plasma using methanol with luliconazole as internal standard.
Performed high-performance liquid chromatography under isocratic conditions with specified mobile phase.
Analyzed 44 plasma samples from 5 patients to determine plasma concentrations.
Calibration curve for belumosudil showed linearity from 250 to 15,000 ng/mL (r2 = 0.9998).
Chromatographic analysis demonstrated no interference from biological matrix or medications.
Validated method is suitable for therapeutic drug monitoring in clinical practice.

Gando et al. (2026) studied this question.

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Randomized trial quantifies belumosudil levels in patients with chronic graft-versus-host disease, suggesting improved therapeutic monitoring.