Key result
Intravenous adenosine administered to healthy volunteers produced a transient bradycardia followed by sinus tachycardia, both significantly related to the logarithm of the dose.
Why the study?
Does intravenous adenosine affect heart rate in healthy adult subjects?
Does intravenous adenosine affect heart rate in healthy adult subjects?
Intravenous adenosine produces a dose-dependent transient bradycardia (due to sinus rate reduction or AV block) followed by sinus tachycardia in healthy adults.
Transient HR effects in healthy volunteers should not change practice; leaves open dose-response in patients.
Adenosine was administered in increasing intravenous bolus doses to nine healthy volunteers. A transient decrease in heart rate was observed which occurred about 20 s after injection. This was due to a reduction in sinus rate and/or transient block of conduction through the atrioventricular node, and lasted less than 10 s. An increase in sinus rate which followed any transient bradycardia was also observed. The maximum bradycardia and maximum tachycardia were each significantly related to the logarithm of adenosine dose.
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Watt et al. (1986) studied Healthy (n=9). Intravenous adenosine was evaluated on Heart rate changes (bradycardia and tachycardia). Intravenous adenosine administered to healthy volunteers produced a transient bradycardia followed by sinus tachycardia, both significantly related to the logarithm of the dose.
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