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July 5, 2026MedicineOpen Access

Immune cell phenotypes in the context of diabetic nephropathy: A Mendelian randomization analysis

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Authors

KTKeke TongHunan University of Traditional Chinese MedicineJDJuan DengHunan University of Traditional Chinese MedicineYYYunfeng YuFirst Affiliated Hospital of Hunan University of Traditional Chinese Medicine

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Implication

Randomized trial shows immune cell phenotypes influence susceptibility to diabetic nephropathy, suggesting immune involvement in its mechanisms.

Key Points

  • This research aims to determine if specific immune cell phenotypes have a causal effect on diabetic nephropathy using Mendelian randomization.
  • Mendelian randomization analysis using genetic datasets from genome-wide association studies and the FinnGen consortium.
  • Inverse-variance weighted approach as the primary analytical framework with complementary analyses for robustness.
  • Evaluation for horizontal pleiotropy and heterogeneity using MR-Egger regression and Cochran Q test.
  • Increased CD25 on IgD− CD38dim shows OR: 1.153, P = .026, linked to higher DN susceptibility.
  • Decreased SSC-A on CD4+ cells shows OR: 0.385, P < .001, linked to lower DN susceptibility.
  • No evidence of horizontal pleiotropy and significant heterogeneity found in analyses.

Cite This Study

Tong et al. (2026) studied this question.

synapsesocial.com/papers/6a49f464f5d1d45b287fff2ehttps://doi.org/10.1097/md.0000000000049443
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