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July 5, 2026npj Precision OncologyOpen Access

Proliferation- and cytotoxic immune signatures identify chemotherapy-responsive bladder tumors in a molecular subtype dependent manner

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Authors

AZAymeric ZadoroznyjPEPontus ErikssonCBCarina Bernardo

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Overview

Randomized trial identifies tumor gene signatures predicting chemotherapy response in muscle-invasive bladder cancer, implying improved treatment allocation.

Key Points

  • The study aims to identify mRNAs that predict response to neoadjuvant chemotherapy in muscle-invasive bladder cancer based on molecular subtypes.
  • Included three NAC-treated cohorts with tumor transcriptomic profiles.
  • Conducted differential mRNA-expression analysis and subtype classification using the Lund Taxonomy.
  • Selected candidate biomarkers for validation based on survival associations of top genes in NAC-cohorts.
  • Proliferation genes predicted response in Urothelial-like subtype, validated by CCNB1 immunostaining.
  • Cytotoxic T- and NK-cell-related genes predicted response in Basal/Squamous tumors, validated by NKG7 immunostaining.
  • The integrative framework allows for ongoing updates as new data becomes available.

Cite This Study

Zadoroznyj et al. (2026) studied this question.

synapsesocial.com/papers/6a49f70df5d1d45b288011dahttps://doi.org/10.1038/s41698-026-01588-7
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