Key result
Overexpression of human sPLA2 in transgenic mice significantly increased the fractional catabolic rate of HDL compared with wild-type controls (4.08 vs 2.16 pools/day).
Why the study?
Does overexpression of human sPLA2 promote HDL catabolism in transgenic mice?
Population
Transgenic mice that specifically overexpress human sPLA2 but have no evidence of local or systemic…
Comparison
Overexpression of human secretory phospholipase A2 vs Control wild-type littermates
Design
Preclinical
Authors
Loading...
Suggests sPLA2 drives HDL catabolism in mice; leaves open relevance to human inflammatory dyslipidemia.
Does overexpression of human sPLA2 promote HDL catabolism in transgenic mice?
Absolute Event Rate: 4.08% vs 2.16%
Overexpression of sPLA2 in the absence of inflammation causes rapid catabolism and altered tissue uptake of HDL cholesteryl ester and apoA-I in vivo, providing a mechanistic basis for reduced HDL in inflammatory conditions.
Tietge et al. (2000) studied HDL metabolism. Overexpression of human sPLA2 vs. Control wild-type littermates was evaluated on Fractional catabolic rate (FCR) of (125)I-HDL (pools/day). Overexpression of human sPLA2 in transgenic mice significantly increased the fractional catabolic rate of HDL compared with wild-type controls (4.08 vs 2.16 pools/day).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: