Key result
Serum miRNA-27a/b expression was significantly higher in patients with familial hypercholesterolemia compared to healthy individuals (fold change 2.21, p=0.001), with the highest levels observed in homozygous patients.
Why the study?
The study was conducted to evaluate the serum level of miRNA-27 expression in patients with familial hypercholesterolemia.
Does miRNA-27a/b expression differ between patients with familial hypercholesterolemia and healthy subjects?
Case-Control (n=59)
Does miRNA-27a/b expression differ between patients with familial hypercholesterolemia and healthy subjects?
miRNA-27a/b expression is elevated in patients with familial hypercholesterolemia and correlates with disease severity (homozygous vs heterozygous), suggesting its potential as a biomarker.
miRNA-27a/b elevation in FH is hypothesis-generating; larger studies needed before biomarker consideration.
Introduction We aimed to evaluate the serum level of miRNA-27 expression in patients with familial hypercholesterolemia (FH). Material and methods miRNA-27a/b levels in serum were compared between 39 patients with heterozygous FH (HeFH = 20) and homozygous FH (HoFH = 19), and 20 healthy subjects (control group). The expression level of miRNA-27a/b was measured using real-time PCR. Results miRNA-27a/b expression in heFH patients (fold change: 2.21 ±0.69, p = 0.001) and in the subgroup of hoFH (fold change: 3 ±1.19, p = 0.001) was significantly higher compared to healthy people. In the comparison between HoFH and HeFH, the HoFH group had a significantly higher level of miRNA-27a/b expression (FC: 1.84 ±1.19, p = 0.009). Conclusions We observed higher miRNA-27a/b expression in patients with FH than in healthy individuals. In comparison with HoFH and HeFH groups, the former had a higher expression level of miRNA-27a/b, which indicates the potential of miRNA-27a/b as a candidate marker for the severity of disease in individuals with FH.
No takes yet. Share an insight, caveat, or question.
Keshavarz et al. (2022) conducted a case-control in Familial hypercholesterolemia (n=59). Familial hypercholesterolemia vs. Healthy subjects was evaluated on Serum miRNA-27a/b expression (Fold change 2.21, p=0.001). Serum miRNA-27a/b expression was significantly higher in patients with familial hypercholesterolemia compared to healthy individuals (fold change 2.21, p=0.001), with the highest levels observed in homozygous patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: