Key result
Residual CV risk persists despite optimal statin therapy, driven by inflammatory and lipid factors.
Why the study?
Residual risk in patients with atherosclerosis remains an urgent problem of modern cardiology despite its controversial aspects.
This review highlights the importance of assessing and managing residual inflammatory and lipid risks for secondary prevention in patients with atherosclerotic cardiovascular disease.
Residual risk assessment may inform ASCVD secondary prevention; leaves open optimal targeting of inflammatory versus lipid pathways in trials.
The residual risk in patients with atherosclerosis, despite the its controversial aspects, remains an urgent problem of modern cardiology. The article presents a review of publications on the prevalence and significance for determining the prognosis of residual risk, which is currently interpreted as the risk of macroand microvascular complications in patients with atherosclerotic cardiovascular disease (ACVD) taking standard therapy, with the achievement of optimal levels of low-density lipoprotein cholesterol, blood pressure and glucose. Based on available publications, we highlighted current views on the factors associated with residual inflammatory and lipid risks in ACVD patients, including those associated with heart failure and diabetes, and the prognostic significance of residual risk in such patients. An attempt was made to rationale the significance of determining the residual risk for secondary prevention of cardiovascular events.
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Хазова et al. (2023) conducted a review in Atherosclerotic cardiovascular disease (ACVD). Residual inflammatory and lipid risk was evaluated. Residual cardiovascular risk remains an important clinical problem in patients with atherosclerotic cardiovascular disease despite optimal statin therapy, driven by both inflammatory and lipid factors.
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