Key result
Sildenafil was reported as a treatment for severe, chronic pulmonary hypertension in three children, following its successful use in adults.
Why the study?
Does sildenafil improve outcomes in children with severe, chronic pulmonary hypertension?
Does sildenafil improve outcomes in children with severe, chronic pulmonary hypertension?
This report describes the use of sildenafil for severe, chronic pulmonary hypertension in a pediatric population.
Hypothesis-generating for sildenafil in severe pediatric pulmonary hypertension; leaves open need for randomized confirmation before practice change.
Severe, chronic pulmonary hypertension in childhood is uncommon, difficult to treat, and carries a poor prognosis. Sildenafil (Viagra, Pfizer) has been used successfully in adults with pulmonary hypertension as monotherapy or in combination with inhaled prostacyclin. Here we report on its use in three children.
No takes yet. Share an insight, caveat, or question.
Will Carroll (2003) studied this question. Sildenafil was reported as a treatment for severe, chronic pulmonary hypertension in three children, following its successful use in adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: