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Demonstrates precision delivery of a singlet oxygen battery in malignancies, suggesting a novel treatment approach.
A precision engineered singlet oxygen battery (GUIDE-SOB) integrates tumor specific recognition with enzyme-instructed self-assembly, enabling spatiotemporally confined membrane lipid peroxidation without continuous irradiation. This strategy provides durable membrane anchoring and hypoxia-tolerant oxidative injury, offering a potent platform for treating deep-seated and therapy resistant malignancies. More in the Research Article (e4426401), Jingtian Zhang, Lili Wang, Jianwu Tian, Dan Ding, and co-workers.
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Wang et al. (2026) studied this question.
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