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July 4, 2026International Journal of Bioinformatics Research and Applications

Discovery of Putative LpxC Inhibitors against Klebsiella pneumoniae: An Early-Stage Rationale Structure-Based Drug Design

Manish Bhadana Rashmi Prabha Singh Monika Jain Jayaraman Muthukumaran Amit Kumar Singh

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Key Points

The aim is to discover potential LpxC inhibitors for treating Klebsiella pneumoniae infections using rational drug design.
Utilized structure-based drug design techniques for inhibitor discovery.
Focused on identifying molecules targeting the LpxC enzyme in Klebsiella pneumoniae.
Preliminary candidates for LpxC inhibition were identified.
Initial screenings suggest effectiveness against Klebsiella pneumoniae.

Implication

Early-stage rationale identifies potential LpxC inhibitors against Klebsiella pneumoniae, suggesting novel treatments.

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Cite This Study

Bhadana et al. (2026) studied this question.

synapsesocial.com/papers/6a4b45b2997070ff83b5b56b https://doi.org/10.1504/ijbra.2027.10079644

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Structure-Based Discovery of a New LpxH-Targeted Chemotype with Activity against <i>Klebsiella pneumoniae</i>Original Research · 2026
2Discovery and Optimizationof Novel NonhydroxamateLpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-NegativeInfectionsEarly-Phase Clinical Trial · 2026
3In Silico Analysis of Neem-Derived Proteins as Inhibitors of Key Antimicrobial Resistance Determinants in Gram-Positive and Gram-Negative BacteriaOriginal Research · 2026
4Evaluation in vitro and in silico of LIG08, a benzoxathiolone-thiazolidinone derivative, as a potential drug against Klebsiella pneumoniaeIn Vitro Study · 2026
5Antibacterial Drug Discovery Targeting the Lipopolysaccharide Biosynthetic Enzyme LpxCOriginal Research · 2016 · 117 citations

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